Sicherheit einer Argininsupplementierung bei Erwachsenen

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    US-Wissenschaftler untersuchten die Verträglichkeit verschiedener Arginindosen.

    Sie konnten nachweisen, dass die Studienteilnehmer orale Dosen von 15 und 30 Gramm Arginin pro Tag ohne nachteilige Effekte tolerierten. Die Serumkonzentrationen von Arginin stiegen progressiv mit den oralen Arginindosen von 0 bis 30 Gramm am Tag an. Eine Supplementierung von 30 Gramm Arginin pro Tag reduzierte den systolischen Blutdruck und die Glukosekonzentrationen bei Frauen – ebenso wie die Serumkonzentrationen der freien Fettsäuren bei Männern und Frauen.

    Zitat


    Safety of dietary supplementation with arginine in adult humans.
    McNeal CJ1, Meininger CJ2, Wilborn CD3, Tekwe CD4, Wu G5,6.

    Abstract
    Previous studies with animals and humans have shown beneficial effects of dietary supplementation with L-arginine (Arg) on reducing white fat and improving health. At present, a long-term safe level of Arg administration to adult humans is unknown. The objective of this study was to conduct a randomized, placebo-controlled, clinical trial to evaluate the safety and tolerability of oral Arg in overweight or obese but otherwise healthy adults with a body mass index of ≥ 25 kg/m2. A total of 142 subjects completed a 7-day wash-in period using a 12 g Arg/day dose. All the remaining eligible 101 subjects who tolerated the wash-in dose (45 men and 56 women) were assigned randomly to ingest 0, 15 or 30 g Arg (as pharmaceutical-grade Arg-HCl) per day for 90 days. Arg was taken daily in at least two divided doses by mixing with a flavored beverage. At Days 0 and 90, blood pressures of study subjects were recorded, their physical examinations were performed, and their blood and 24-h urine samples were obtained to measure: (1) serum concentrations of amino acids, glucose, fatty acids, and related metabolites; and (2) renal, hepatic, endocrine and metabolic parameters. Our results indicate that the serum concentration of Arg in men or women increased (P < 0.05) progressively with increasing oral Arg doses from 0 to 30 g/day. Dietary supplementation with 30 g Arg/day reduced (P < 0.05) systolic blood pressure and serum glucose concentration in females, as well as serum concentrations of free fatty acids in both males and females. Based on physiological and biochemical variables, study subjects tolerated oral administration of 15 and 30 g Arg/day without adverse events. We conclude that a long-term safe level of dietary Arg supplementation is at least 30 g/day in adult humans.


    https://www.ncbi.nlm.nih.gov/pubmed/29858688

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