Serum Testosterone / Testicular Size / Reuteri

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    Lactobacillus reuteri Consumption Increases Testicular Weight of Mice Fed with Normal Diet

    We observed unusually large testes and social dominance behaviors in male mouse models while feeding probiotic yogurt or purified lactic acid bacteria during obesity and cancer studies (Figure 1a). To test specific effects of probiotics on testes, outbred Swiss mice on normal (control) diet were given Lactobacillus reuteri ATCC 6475 using a dosage of 3.5×105 organisms/mouse/day starting at 2 months of age and their testes were weighed at 3, 5, 7 and 10 months later. At each time-point the weight of testes from mice consuming probiotics was significantly higher than that of control mice. Specifically, at five months (CD vs CD+LR, P = 0.0408) (Fig. 1b), seven months (CD vs CD+LR, P = 0.0328) (Fig. 1c), nine months (CD vs CD+LR, P = 0.0178) (Fig. 1e), and 12 months of age (CD vs CD+LR, P = 0.0062) (Fig. 1e) the statistical significance of testes weight difference between probiotic-treated and non-treated groups of mice progressively increased with age. When the testes weight values were adjusted for body weight (testis weight/body weight ratio) the L. reuteri effect was more pronounced in all different age time-points examined (Fig. S1). While feeding of L. reuteri consistently increased the gonadal weights, consumption of a non-pathogenic strain of Escherichia coli (E. coli) K12 organisms did not affect testicular weight (CD+E.coli vs CD+LR, P = 0.026) (Fig. 1c) or the testicular/body weight ratio when compared at age 7 months, confirming the specificity of the probiotic organism effect (Fig. S1).





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