Mitochondrial DNA Damage in Iron Overload

Dieses Thema enthält 1 Antwort und 2 Teilnehmer. Es wurde zuletzt aktualisiert von Zopiclon Zopiclon 26.05.2018 um 06:14.

Ansicht von 2 Beiträgen - 1 bis 2 (von insgesamt 2)
  • Autor
    Beiträge
  • #90119 hilfreich: 0
    Markus
    Markus
    Teilnehmer
    8 pts
    Beiträge: 2646

    Zitat


    Chronic iron overload has slow and insidious effects on heart,
    liver, and other organs. Because iron-driven oxidation of most
    biologic materials (such as lipids and proteins) is readily
    repaired, this slow progression of organ damage implies some
    kind of biological “memory.” We hypothesized that cumulative
    iron-catalyzed oxidant damage to mtDNA might occur in iron
    overload, perhaps explaining the often lethal cardiac dysfunction.
    Real time PCR was used to examine the “intactness” of
    mttDNA in cultured H9c2 rat cardiac myocytes. After 3–5 days
    exposure to high iron, these cells exhibited damage to mtDNA
    reflected by diminished amounts of near full-length 15.9-kb
    PCR product with no change in the amounts of a 16.1-kb product
    from a nuclear gene. With the loss of intact mtDNA, cellular
    respiration declined and mRNAs for three electron transport
    chain subunits and 16 S rRNA encoded by mtDNA decreased,
    whereas no decrements were found in four subunits encoded by
    nuclear DNA. To examine the importance of the interactions of
    iron with metabolically generated reactive oxygen species, we
    compared the toxic effects of iron in wild-type and rhoo cells. In
    wild-type cells, elevated iron caused increased production of
    reactive oxygen species, cytostasis, and cell death, whereas the
    rhoo cells were unaffected. We conclude that long-term damage
    to cells and organs in iron-overload disorders involves interactions
    between iron and mitochondrial reactive oxygen species
    resulting in cumulative damage to mtDNA, impaired synthesis
    of respiratory chain subunits, and respiratory dysfunction.


    http://m.jbc.org/content/284/8/4767.full.pdf

    #126108 hilfreich: 0
    Zopiclon
    Zopiclon
    Teilnehmer
    5 pts
    Beiträge: 515

    Ja natürlich hat man ein Problem,wenn man die oxidierenden Stoffe anhebt und mögliches RedOx Potential nicht zuführt, dafür brauch man doch keine Studie

    Was will uns das sagen? Nichts neues, denn ein zuviel und zu wenig ist immer schlecht. Das zu viel oder zu wenig ist aber abhängig von anderen (semi)essentiellen Stoffen …

    Gruss

Ansicht von 2 Beiträgen - 1 bis 2 (von insgesamt 2)

Sei müssen angemeldet sein, um auf dieses Thema antworten zu können.