increased ferritin concentrations represent a biological biomarker predictive of early death in a dose-dependent linear manner

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    minimal disease risk and maximal longevity, with concentrations of about 70 μg/L to 100 μg/L

    Cause-specific mortality below vs above the 200 ?g/L threshold was significantly lower for cancer (P = 0.005), metabolic disease (P = 0.002) and cardiovascular disease (P = 0.00006). A highly significant progressive decrease in median survival occurred with increasing ferritin concentrations. The hazard ratio for total mortality increased by 13% for each 100 ?g/L increase in ferritin concentration. The median survival was 79 years with concentrations <200 ?g/L, 76 years with ferritin concentrations between 200 and 399 ?g/L, 72 years with ferritin concentrations between 400 and 599 ?g/L, and 55 years with ferritin concentrations in excess of 600 ?g/L. A stepwise increase in mortality with increasing ferritin concentrations was found for each disease category.

    http://clinchem.aaccjnls.org/content/60/11/1362

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