Cholin und O3: Neuroplastizität anhand eines plastischen Beispiels

Dieses Thema enthält 6 Antworten und 2 Teilnehmer. Es wurde zuletzt aktualisiert von Chris Michalk Chris Michalk 06.06.2014 um 17:13.

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  • #87343 (0)
    Markus
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    Im longecity-Forum hat ein Moderator seine schwangere und später stillende Frau mit Alpha-GPC (Blut-Hirnschranke- und Plazentagängige Form von Cholin), Omega 3 und Uridine-UMP "gefüttert"

    Das Ergebnis kann sich sehen lassen, es werden aber nur Leute, die bereits Eltern sind, so recht zu würdigen wissen:

    She started rolling over and trying to crawl at 3 weeks. Good muscle tone and already holding her head up. Started appreciating art at 3 weeks – likes to be carried around our place looking at paintings and indicates when she want to move to the next one by leaning at the one she wants. Complains if you go to the wrong one. Originally preferred paintings with high contrasts, now likes more colourful work. Loves music, unless it’s ‚bad‘ and then she lets you know to change it. Likes Vivaldi and Mozart and a lot of modern stuff.

    Started talking, in context, at 5 weeks: Mum, dad, hug, hello, yes, boob, mama and thank you (which sounds like ‚ankoo‘, without teeth.) Favourite words are hello, mum and boob. The latter 2 when she wants to be fed. Great coordination, aim and spatial awareness. She ‚owns‘ the mobile when she is under it. Started doing squats and trying to walk around 9 weeks. Not there yet – balance is the issue. Started trying to sing at 11 weeks – joins in with mum whenever she sings something she likes.

    Great sense of humour and lots of non-verbal communication, too. The smiles and baby-giggles are heart melting. Doesn’t cry much – maybe 3-5 minutes out of a day, although she started teething at 12 weeks, so that changed a bit until we helped her manage it, by showing her our teeth, so she understood what was happening and getting her to gum down on a strip of capsicum to numb the pain.

    As I’m writing this, her mum is holding her up to the electric piano and she’s making an unholy din.
    http://www.longecity.org/forum/topic/518…ine-uridine-dha

    #92296 (0)
    Chris Michalk
    Chris Michalk
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    Cholin, DHA, Uridin-Kombi entspricht einer Arbeit von Wurtman (2009).

    DISCUSSION AND CONCLUSION: Uridine and DHA are circulating precursors for the phosphatides in synaptic membranes, and act in part by increasing the substrate-saturation of enzymes that synthesize phosphatidylcholine from CTP (formed from the uridine, via UTP) and from diacylglycerol species that contain DHA: the enzymes have poor affinities for these substrates, and thus are unsaturated with them, and only partially active, under basal conditions. The enhancement by uridine of neurite outgrowth is also mediated in part by UTP serving as a ligand for neuronal P2Y receptors. Moreover administration of uridine with DHA activates many brain genes, among them the gene for the m-1 metabotropic glutamate receptor [Cansev, et al, submitted]. This activation, in turn, increases brain levels of that gene’s protein product and of such other synaptic proteins as PSD-95, synapsin-1, syntaxin-3 and F-actin, but not levels of non-synaptic brain proteins like beta-tubulin. Hence it is possible that giving uridine plus DHA triggers a neuronal program that, by accelerating phosphatide and synaptic protein synthesis, controls synaptogenesis. If administering this mix of phosphatide precursors also increases synaptic elements in brains of patients with Alzheimer ’s disease, as it does in normal rodents, then this treatment may ameliorate some of the manifestations of the disease.

    #92297 (0)
    Chris Michalk
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    Aber es ist immer wieder schön zu sehen, dass so etwas dann tatsächlich auch im wahren Leben funktioniert. Haha, n=1 Studien sind die besten :-)

    #92298 (0)
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    Ah, danke. Das ist genau die Arbeit, die Dr. Strunz vor Jahren mal erwähnt hatte:

    http://www.strunz.com/news.php?newsid=665

    Nur angewandt im Kreissaal anstatt an Alzheimer-Greisen.

    #92299 (0)
    Chris Michalk
    Chris Michalk
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    Ja, wobei Strunz sich glaube ich auf folgende Arbeit von Wurtman bezogen hat:
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2578826/

    If pregnant rats are fed the three dietary constituents needed for PC synthesis – docosahexaenoic acid (DHA), uridine, and choline – starting 10 days before parturition and continuing for 20 days during nursing, brain levels of PC and of the other membrane phosphatides (per cell or per mg protein) are increased by 50% or more. In adult animals this treatment is also known to increase synaptic proteins (e.g. synapsin-l; syntaxin-3; GluR-l; PSD-95) but not ubiquitous proteins like beta-tubulin, and to increase (by 30% or more) the number of dendritic spines on hippocampal neurons

    #92300 (0)
    Chris Michalk
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    Ich frage mich, ob Uridin zwingend exogen zugeführt werden muss.

    #92301 (0)
    Chris Michalk
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    Taken together these data indicate that uridine can regulate the output of neurites from differentiating PC12 [corrected] cells, and suggest that it does so in two ways, i.e. both by acting through cytidine triphosphate as a precursor for phosphatidylcholine biosynthesis and through uridine triphosphate as an agonist for P2Y receptors.

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