Aging of the nitric oxide system: are we as old as our NO?

Dieses Thema enthält 1 Antwort und 2 Teilnehmer. Es wurde zuletzt aktualisiert von Chris Michalk Chris Michalk 17.07.2015 um 15:51.

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  • #88466 hilfreich: 0
    10 pts
    Beiträge: 2653

    Vorsichtiges Fazit der Autoren: Wir sind so alt wie unser NO

    J Am Heart Assoc. 2014 Aug 18;3(4). pii: e000973. doi: 10.1161/JAHA.114.000973.

    Aging of the nitric oxide system: are we as old as our NO?
    Sverdlov AL1, Ngo DT1, Chan WP1, Chirkov YY1, Horowitz JD1.


    Impaired generation and signaling of nitric oxide (NO) contribute substantially to cardiovascular (CV) risk (CVR) associated with hypertension, hyperlipidemia, and diabetes mellitus. In our rapidly aging society, advanced age is, in itself, a consistent and independent CVR factor. Many processes involved in aging are modulated by NO. We therefore postulated that aging might be independently associated with impaired NO signaling.

    In a prospective cohort study of 204 subjects (mean age 63±6 at study entry), we evaluated the effects of 4 years of aging on parameters of NO generation and effect, including platelet aggregability and responsiveness to NO, and plasma concentrations of the NO synthase inhibitor, asymmetric dimethylarginine (ADMA). Clinical history, lipid profile, high-sensitivity C-reactive protein, routine biochemistry, and 25-hydroxyvitamin D levels were obtained at study entry and after 4 years of follow-up. Aging was associated with marked deterioration of responsiveness of platelets to NO (P<0.0001) and increases in plasma ADMA concentrations (P<0.0001). There was a significant correlation between changes in these parameters over time (r=0.2; P=0.013). On multivariable analyses, the independent correlates of deterioration of responsiveness of platelets to NO were female gender (β=0.17; P=0.034) and low vitamin D concentrations (β=0.16; P=0.04), whereas increases in ADMA were associated with presence of diabetes (β=0.16; P=0.03) and impaired renal function (β=0.2; P=0.004).

    Aging is associated with marked impairment of determinants of NO generation and effect, to an extent which is commensurate with adverse impact on CV outcomes. This deterioration represents a potential target for therapeutic interventions.

    #109299 hilfreich: 0
    Chris Michalk
    Chris Michalk
    50 pts
    Beiträge: 2524

    Na das ist mal etwas sehr Geiles!

    Die Wissenschaft hinter NO ist auf jeden Fall mega spannend und ich glaube mittlerweile ernsthaft, dass es zu den wichtigsten Dingen gehört, sich um sein NO-System zu kümmern.

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